Jan Nedergaard

Prof. dr. Jan Nedergaard
The Wenner-Gren Institute
The Arrhenius Labs F3
Stockholm University
SE-106 91 Stockholm
SWEDEN
Tel +46 8 164128
Fax + 46 8 156756
E-mail: jan@metabol.su.se


Expertise:
Specialist in mitochondrial bioenergetics and influence of oxidative metabolism on energy balance and free radical generation. Special interest in uncoupling protein 1 (UCP-1) and the function, physiological significance, growth and differentiation of brown adipose tissue.


Relevant projects and functions:

• Dean, Biological Sciences, Stockholm University
• Secretary, National Committee for Physiology, Pharmacology and Neuroscience, Sweden
• Editorial advisory panel member, Biochemical Journal
• Editorial advisory board member, Journal of Comparative Physiology
• Editorial board member, Adipocytes

Group structure:
1 Professor (M); 1 lecturer (M), 1 post-doc (F); 5 doctoral students (1M, 4F); 1 technician (F)


Selected publications:
1. Shabalina IG, Petrovic N, Kramarova TV, Hoeks J, Cannon B and Nedergaard J (2006); UCP1 and defense against oxidative stress: 4-Hydroxy-2-nonenal effects on brown-fat mitochondria are uncoupling protein-1 independent. J. Biol. Chem. 281, 13882-13893
2. Shabalina IG, Jacobsson A, Cannon B, Nedergaard J (2004): Native UCP1 displays simple competitive kinetics between the regulators purine necleotides and fatty acids. J. Biol. Chem. 279, 38236-38248

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